Journal of Allergy and Clinical Immunology
Publish at 18.11.2019
Presentation
Molecular basis of altered immune homeostasis
Our work is at the interface between immunology, cell biology and genetics. We aim to determine the pathophysiological mechanisms underlying severe alterations of immune homeostasis using rare monogenic disorders as paradigm. This approach offers unique opportunities for describing key physiological processes, as well as complex disease-causing mechanisms, allowing us to develop new diagnostic and therapeutic tools.
In this context, we are developing two main research axes:
Decoding the cellular, molecular and genetic basis of haemophagocytic lymphohistiocytosis (HLH).
HLH is a unique immunopathological phenotype characterized by uncontrolled expansion and activation of polyclonal T lymphocytes and hyperinflammation. Over the years, we have greatly contributed to establish the relationship between genetic defects affecting cytotoxic activity of lymphocytes and HLH development. However, several inherited cases of HLH present without impairment in lymphocytes’ cytotoxicity, indicating that defects in other regulatory mechanism(s) could contribute to HLH development. The goal of our research intends to unveil new immunoregulatory mechanism(s) critical to maintain immune homeostasis, by identifying new genetic defects responsible of HLH cases presenting with normal cytotoxic activity of lymphocytes.
A M2 student position is currently available. For more information contact fernando.sepulveda@inserm.fr
Cellular and molecular dissection of inherited cases of severe allergies.
Allergies result from an inappropriate immune response against otherwise harmless antigens. Although we now have a better understanding of allergic disease development, it has become clear that associated complex phenotypes involve many different inflammatory circuits and signalling pathways in effector cells calling for novel research to delineate the underlying mechanisms. The goal of our research is designed to (i) discover new molecular effectors of allergic reactions (i.e. drug targets), and (ii) understand severe allergic diseases at the genomic and transcriptomic levels.
Team
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Gaël Ménasché
chef d'équipe
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Fernando Sepulveda
Team Leader
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Geneviève de Saint Basile
Research Director Emeritus
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Guillaume LEZMI
MCU-PH
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Mathieu Kurowska
Assistant ingénieur (INSERM)
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Sara Mouasni
Post-Doctoral Researcher
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Tania Gajardo
PhD student
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Cyril Longe
PhD student
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Valère Desmeure
PhD student
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Pierre Duquesne
Etudiant en thèse
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Patricia Panikulam
PhD student
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Alexandre Deslys
M2 student
Resources & publications
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Arterioscler. Thromb. Vasc. Biol.
Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.
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Cell Mol Gastroenterol Hepatol
Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation...
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Proc. Natl. Acad. Sci. U.S.A.
Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowe...
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Curr. Opin. Immunol. 2018
Hemophagocytic syndrome: primary forms and predisposing conditions.